Watch Katie Couric Imitate Sydney Sweeney in New Colon Cancer Screening PSA

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Katie Couric Channels Sydney Sweeney in Colon Cancer Awareness PSA: “Screenings Save Lives”

Katie Couric is using humor and pop culture to deliver a serious message about colon cancer screening in a new public service announcement — and she’s doing it by spoofing Sydney Sweeney’s much-talked-about American Eagle commercial.

“That ad showed how pop culture and a pair of jeans could really shape the cultural conversation,” Couric, 68, told PEOPLE. “It was everywhere. So we thought, why not ride that wave a little longer and have some fun while spreading an important message?”

The PSA opens with Couric reclining in a denim jacket to the tune of sultry music — an intentional nod to Sweeney’s original ad. But as the camera zooms out, it becomes clear this isn’t your typical fashion promo: Couric is lying on a hospital gurney in a medical gown, moments away from a colonoscopy.

“It was funny for me because, well, I’m a little older than Sydney Sweeney,” Couric joked. “I was trying to get that jean jacket to sit just right.”

In the ad, she opens with a cheeky twist: “Speaking of genes,” she says — mimicking Sweeney’s delivery — “did you know that most people who develop colon cancer don’t have a genetic link to the disease? That’s why doctors recommend everyone 45 and older get screened.”

This campaign is part of the Lead From Behind initiative, spearheaded by the Colorectal Cancer Alliance and Maximum Effort, the creative agency co-founded by Ryan Reynolds.

“The mission of the Colorectal Cancer Alliance is very near to my heart. And my ass,” Reynolds said in a statement. “When Rob [McElhenney] and I livestreamed our colonoscopies to launch Lead From Behind, we were really following in Katie’s footsteps. She did it first — and bravely — 25 years ago.”

Reynolds was referring to Couric’s groundbreaking televised colonoscopy on The Today Show in 2000, which dramatically increased awareness and screening rates across the U.S.

“Having her now involved in this campaign is a full-circle moment — or as I like to call it, a full-starfish moment,” Reynolds added.

Couric’s dedication to raising awareness about cancer screening is deeply personal. Her husband, Jay Monahan, died of colon cancer in 1998 at the age of 42. Since then, she’s become one of the most prominent advocates for early detection.

“I'm a grandmother now,” Couric told PEOPLE. “My girls have graduated college, and these are huge life moments their dad never got to see. I don’t want other families to go through that. So I feel an obligation to share what I’ve learned and encourage screenings.”

She’s remained consistent in her efforts — from taking Jimmy Kimmel for an on-air colonoscopy in 2018 to co-founding major cancer initiatives like the National Colorectal Cancer Research Alliance, Stand Up to Cancer, and the Jay Monahan Center for Gastrointestinal Health.

In the PSA’s closing scene, a narrator announces, “Katie Couric gets regular screenings. And if you’re 45 or older, you should too.” With her signature wit, Couric adds: “Mine are televised.”

Screenings, she says, are too often pushed aside. “People don’t think about it. It’s not at the top of their to-do list. But regular screening can save your life — and that’s something we can’t afford to ignore.”

According to the Mayo Clinic, colorectal cancer typically starts as small, benign growths called polyps, which can develop in the colon without causing symptoms. While not all polyps turn into cancer, removing them early significantly reduces the risk. That’s why early and consistent screening is vital — especially for those over 45.

 

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